منابع مشابه
Granzyme A activates another way to die.
Granzyme A (GzmA) is the most abundant serine protease in killer cell cytotoxic granules. GzmA activates a novel programed cell death pathway that begins in the mitochondrion, where cleavage of NDUFS3 in electron transport complex I disrupts mitochondrial metabolism and generates reactive oxygen species (ROS). ROS drives the endoplasmic reticulum-associated SET complex into the nucleus, where i...
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n page 987, Yu et al. identify a novel cell death pathway that bypasses mito-chondria. The results indicate that various strategies exist to kill off neurons. A lot of the killing of sympathetic neurons occurs in the first week after birth. During that paring period, ف 50% of sympathetic neurons die due to a lack of nerve growth factor (NGF). Neurons deprived of NGF in vitro die through the c...
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Regulated, programmed cell death is crucial for all multicellular organisms. Cell death is essential in many processes, including tissue sculpting during embryogenesis, development of the immune system and destruction of damaged cells. The best-studied form of programmed cell death is apoptosis, a process that requires activation of caspase proteases. Recently it has been appreciated that vario...
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velopment is initiated by transcriptional upregulation of Ivelisse Sánchez and Junying Yuan* Egl-1, another BH3-only member of the BCL-2 family Department of Cell Biology that acts by inhibiting Ced-9, an antiapoptotic member Harvard Medical School of the BCL-2 family (Conradt and Horvitz, 1998). 240 Longwood Avenue BIM may not be the only BH3-only member that is Boston, Massachusetts 02115 ind...
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TRAIL, a putative anticancer cytokine, induces extrinsic cell death by activating the caspase cascade directly (Type I cells) via the death-inducing signaling complex (DISC) or indirectly (Type II cells) by caspase-8 cleavage of Bid and activation of the mitochondrial cell death pathway. Cancer cells are characterized by their dependence on aerobic glycolysis, which, although inefficient in ter...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2010
ISSN: 0105-2896
DOI: 10.1111/j.0105-2896.2010.00902.x